If they ever build a bed bug hall of fame, there will definitely be a spot in the trophy case for 248 McKibben St in Brooklyn, the most-reported address in the New York area, with 33 reports. Its sister building at 255 McKibben has ten reports.
The bedbug problem in this building (and its neighbors) is so severe it's received repeated media coverage, in Gothamist, Gawker, and even a Wikipedia article (which does not mention the bed bug problem).
Curiously enough, a recent Daily News profile of this site interviewed a resident of the building, but did not mention the address.
Bedbugger.com covered this building back in 2007. But it still leads the pack!